I-NHDC (neohesperidin dihydrochalcone) cishe imnandi izikhathi eziyi-1500-1800 kunoshukela, ukunambitheka kwayo okumnandi njenge-licorice.Itholakala kuzithako zemvelo ze-citrus (i-naringin noma i-hesperidin) nge-bio-transformation noma ukuguqulwa kwamakhemikhali.I-NHDC iyisiqinisekisi esisebenzayo, ubumnandi nesithuthukisi ukunambitheka esinezici zokufihla ubuthi ezingenabuthi, ezinekhalori ephansi, ukunambitheka kanye nokubaba.Futhi inomsebenzi othile wokuphila, njenge-antioxidant, ukunciphisa i-cholesterol kanye noshukela wegazi.Isetshenziswa emikhiqizweni eminingi ehlanganisa ukudla, imithi, izithasiselo zokudla, izimonyo kanye nokudla.