Njengamanje, i-neotame ivunyelwe amazwe angaphezu kwe-100 ukuze isetshenziswe ezinhlotsheni zemikhiqizo ezingaphezu kuka-1000.
Ilungele ukusetshenziswa eziphuzweni ezithambile ezine-carbonated, iyogathi, amakhekhe, izimpushana zesiphuzo, izinsini ze-bubble phakathi kokunye ukudla.Ingasetshenziswa njenge-sweetener ephezulu yetafula yeziphuzo ezishisayo njengekhofi.Ihlanganisa ukunambitheka okubabayo .
I-HuaSweet neotame ithobelana nezinga lezwe laseShayina elingu-GB29944 futhi ihlangabezana ngokuqinile nokucaciswa kwe-FCCVIII, USP, JECFA kanye ne-EP.I-HuaSweet isungule inethiwekhi yokuthengisa emazweni angaphezu kwamashumi ayisishiyagalombili kulo lonke elaseNingizimu-mpumalanga ye-Asia, eYurophu, eNingizimu Melika, eNyakatho Melika nase-Afrika.
Ngo-2002, i-FDA yasigunyaza njengesithuthukisi esingenamsoco nesithuthukisi ukunambitheka ngaphakathi kwe-United States ekudleni ngokuvamile, ngaphandle kwenyama nezinkukhu.[3]Ngo-2010, yagunyazwa ukusetshenziswa ekudleni ngaphakathi kwe-EU ngenombolo E961.[5]Iphinde yamukelwa njengesengezo kwamanye amazwe amaningi ngaphandle kwe-US ne-EU.
E-US nase-EU, ukudla okwamukelekile kwansuku zonke (ADI) kwe-neotame kubantu kungu-0.3 no-2 mg ngekhilogremu yesisindo somzimba (mg/kg bw), ngokulandelana.I-NOAEL yabantu ingu-200 mg/kg bw ngosuku ngaphakathi kwe-EU.
Izilinganiso zansuku zonke ezingaba khona ekudleni zingaphansi kwamazinga e-ADI.I-neotame engenisiwe ingenza i-phenylalanine, kodwa ekusebenziseni okuvamile kwe-neotame, lokhu akubalulekile kulabo abane-phenylketonuria.Futhi ayinayo imiphumela emibi kuhlobo 2 sikashukela.Akubhekwa njenge-carcinogenic noma i-mutagenic.
Isikhungo Sesayensi Esithakaselayo Somphakathi silinganisa i-neotame njengephephile.